Definition of sub

• a large sandwich made of a long crusty roll split lengthwise and filled with meats and cheese (and tomato and onion and lettuce and condiments); different names are used in different sections of the United States
• a submersible warship usually armed with torpedoes
• be a substitute; "The young teacher had to substitute for the sick colleague"; "The skim milk substitutes for cream--we are on a strict diet"