Definition of lonesome

• being the only one; single and isolated from others; "the lone doctor in the entire county"; "a lonesome pine"; "an only child"; "the sole heir"; "the sole example"; "a solitary instance of cowardice"; "a solitary speck in the sky"
• marked by dejection from being alone; "felt sad and lonely"; "the loneliest night of the week"; "lonesome when her husband is away"; "spent a lonesome hour in the bar"